Molecular Genetics in Epilepsy
The purpose of this section is to provide a clinically relevant conceptual expertise of the underlying molecular foundation of seizure prevalence alternatively enlisting each gene that has thus far been linked to epilepsy. Each protein in our frame is synthesized from their genes via the procedure of transcription (formation of messenger RNA, mRNA) and translation (synthesis of protein from mRNA). Factors which do no longer necessarily exchange the shape of the gene however do have an effect on the method of transcription and translation is known as epigenetic elements. Any perturbation inside the transcription, translation, or epigenetic mechanisms can produce defective proteins main to diseases. Seizures occur as a result of a complicated interaction of altered gene expressions, expanded neuronal excitability and disturbed intrinsic neuronal properties. Defects in epilepsy genes provide a vital perception into the path mechanisms of seizure era and propagation, which has an effect at the management of the patients as illustrated underneath.
Genotype–phenotype correlation